RUNNING HEAD: Subthalamic nucleus and food-directed motivation
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منابع مشابه
Enhanced food-related motivation after bilateral lesions of the subthalamic nucleus.
Although inactivation of the subthalamic nucleus (STN) has beneficial effects on motor symptoms of parkinsonism, little is known of possible actions on nonmotor symptoms of cognition or mood. Here, we used several forms of converging evidence to show that STN lesions can enhance behavioral motivation. Thus, bilateral fiber-sparing lesions of the STN in rats reduced the time required to eat a st...
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1 with Synaptic Input and Current Injection 2 3 4 Running Head: Phase Response Curves in the Subthalamic Nucleus 5 6 Michael A. Farries and Charles J. Wilson 7 8 Department of Biology, University of Texas San Antonio, San Antonio, TX 9 10 11 12 Corresponding Author: 13 Michael A. Farries 14 Department of Biology, University of Texas San Antonio 15 One UTSA Circle 16 San Antonio, TX 78249 17 mic...
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The search for treatment of cocaine addiction raises the challenge to find a way to diminish motivation for the drug without decreasing it for natural rewards. Subthalamic nucleus (STN) inactivation decreases motivation for cocaine while increasing motivation for food, suggesting that STN can dissociate different rewards. Here, we investigated how rat STN neurons respond to cues predicting coca...
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It is now well established that subthalamic nucleus high-frequency stimulation (STN HFS) alleviates motor problems in Parkinson's disease. However, its efficacy for cognitive function remains a matter of debate. The aim of this study was to assess the effects of STN HFS in rats performing a visual attentional task. Bilateral STN HFS was applied in intact and in bilaterally dopamine (DA)-deplete...
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Deep brain stimulation is associated with delayed improvement of parkinsonian symptoms, such as hypokinesia with subthalamic nucleus stimulation, or dystonia with globus pallidus internus stimulation. The latency observed is better explained by molecular alterations than immediate electrophysiological processes, and clinical improvement may involve adaptive gene expression. Here, we have studie...
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